Studies indicate that ingested oral cyanocobalamin tablets are ineffective saw palmetto supplements in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the liver. when b12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. it is during this first pass in its native form that it is believed to exert its therapeutic effect. clinical research: "the palmetto world health organization (who) recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases in which ige-mediated allergy may be involved."1 in 1988, asthma and allergic rhinitis subjects were treated with b12. total ige, specific ige and pulmonary lung functions supplements were taken at days 45, 150 and 180 from baseline. eight of the 9 subjects had reduced saw palmetto liquid capsule ige. 2 in 1989 open label studies at two sites in riverside county, ca in 1989. sixteen of the 17 subjects had lowered ige levels from day 0 to day 30.3

feeling fine in general, allergy symptoms improved. c. t. have palmetto been doing a lot better. lisa l. so far, so good. andy g. felt supplements congested, but improved. richard bph saw palmetto r. feeling fine. no problems. roland h. feel ok as far as allergies. angel p. i palmetto felt relief after the treatment, supplements and still feeling better. a. v. i feel ok, but have a little congestion. saw carlin r. feel better than before. art p. feel good - continue with sinusitis palmetto bob m. feeling moderate. gustavo m. much better. alejandro m. what patients said after more than two months all my symptoms seem to have gone. margareth z. for the first time after taking the treatment, i felt like my life supplements was my own. after 20 years i was able to go out in traffic and high winds with little or no bad effects. i could even tolerate gas lawn mowers. i was able to walk around without huffing and puffing. pain in throat and lungs disappeared. getting air in lungs.

in january 1997, 62 subjects who had been the placebos in the 1995 study were invited to receive the vitamin b12. in june 1997, the 62 placebo subjects were sent a questionnaire asking: how would you compare your overall allergy (hay fever) symptoms this spring to the last two springs? 20 people responded, with 15 reporting having had the b12 treatment, and 5 not. 12 of the 15 reported at least a slight improvement in overall allergy symptoms, and 1 saw of the 5. improvement ratios - 12:3 having received treatment, 1:4 not having received treatment.8 a bioequivalence study showed that a 3000 mcg lozenge delivered an equivalent amount of cyanocobalamin to the blood as a 15 mcg injection.9 from the spring to the summer patients with demonstrated allergic rhinitis received with the cyanocobalamin (or placebo) containing lozenge twice daily for 21 consecutive days. palmetto all subjects also received c and b oral multivitamins for 21 days. twice daily subjects maintained a nine-week diary on sneezing, runny nose, nasal congestion, supplements itchy eyes, itchy nose and antihistamine (chlorpheniramine) use. in the post-treatment period, the active group (n=15) recorded on average a greater reduction in symptoms and in antihistamine use than the placebo group (n=9). the results yielded reductions (0.1>p>0.01) in total weekly symptom/rescue medication for the active group compared to the placebo for weeks 2, 6, 8 and 9. the results tend to replicate those of the studies on injectable cyanocobalamin.10