In 1990 study in San Diego, CA the 5 active subjects with allergic rhinitis had a lowered total serum IgE from Day 0 to Day 90 while 4 placebo subjects, (2 with allergic rhinitis, 1 with asthma and 1 with both), had flat or increased IgE levels.4 In a randomized, double-blind, placebo controlled study of symptoms and serum IgE levels in San Diego, CA in mid-1991, subjects had allergic rhinitis and/or asthma. Serum was drawn at Day 0 and Day 30. Seven sea cucumber of the 10 active treated subjects cucumber had a reduction in total serum ige levels. in 10 powder placebo treated subjects, 5 sea had levels of total serum ige that stayed the same (plus or minus 5%), 3 decreased and 2 increased.5 statistical analysis of the open-label study as well as the double-blind randomized placebo controlled study have shown a significant effect of vitamin b12 in lowering serum ige concentrations.

studies indicate cucumber that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the liver. when b12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. it is during this first pass powder in its native form that it is believed to exert its therapeutic effect. clinical research: "the world health organization (who) recognizes allergic rhinitis sea (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine cucumber and powder headache...as diseases in which ige-mediated allergy may be involved."1 in 1988, asthma and allergic rhinitis subjects were treated with b12. total ige, specific ige and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. eight of the 9 subjects had reduced ige. 2 in 1989 open label studies at two sites in riverside county, ca in 1989. sixteen of the 17 subjects had lowered ige levels from day 0 to day 30.3