In 1990 study in San Diego, CA the soy chromium and antioxidants antioxidants and disease prevention 5 active subjects with allergic rhinitis had a lowered total serum ige from day 0 to day 90 while 4 placebo subjects, (2 with allergic rhinitis, 1 with asthma and 1 with both), had flat or increased ige levels.4 in a randomized, double-blind, placebo controlled antioxidants and soy study of symptoms and serum ige levels in san diego, ca in mid-1991, subjects had allergic rhinitis and/or asthma. serum was drawn at day 0 and day 30. seven of the and 10 active treated subjects had a reduction in total serum ige antioxidants levels. in 10 placebo treated subjects, 5 had levels of total serum ige that stayed the same (plus or minus 5%), 3 decreased and 2 soy increased.5 statistical analysis of the open-label study as well as the double-blind randomized placebo and controlled study have shown a significant effect of vitamin b12 in lowering serum ige concentrations.

studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the liver. when b12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. it is during this first pass in its native form that it is believed to exert its therapeutic effect. clinical research: "the world health organization (who) recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, antioxidants and soy urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases in which ige-mediated allergy may be involved."1 in 1988, asthma and allergic rhinitis subjects were treated with b12. total ige, specific ige and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. eight of the 9 subjects had reduced ige. 2 in 1989 open label studies at two sites in riverside county, ca in 1989. sixteen of the 17 subjects had lowered ige levels and from day antioxidants 0 to day 30.3